risk management plan in pharmacovigilance pdf

www.jliedu.com . endobj ?||'V_VBKQ|{*/>M?y-t-^Xgar3KYU)Z]*Qm^|/,J&TfrUWf%ME(CO?Zbz?2,Og31%|Lw.gM!"V%%V0c*ZSWl2H %VN6]r)&TMb*'^OI3 NzNvO[C4S e. endobj u=K+@rsKIX9ThR5+F=Wyxlq8^8MD)0gM 21 0 obj characterize, prevent or minimize risks relating to medicinal products including the, assessment of the effectiveness of those activities and interventions, is a term used to describe the overall process or, Identify hazards and risk factors that have t, Analyze and evaluate the risk associated with that hazard (risk analysis, and, Determine appropriate ways to eliminate the hazard, or control the risk when. endobj x\[s7~w`O*UNxwu{hD-Itn\q+Tr /zwngegv7? /Contents 36 0 R>> Plans (Pharmacovigilance Plan) 10 08. <> In some companies some activities may be performed by different departments, for example, endobj Routine Pharmacovigilance Activities Reporting of adverse reactions and signal detection Update on significant safety information Update of actions taken by other regulatory agencies 3.2. The risk management system is defined as a set of pharmacovigilance activities and interventions designed to identify, characterise, prevent or minimise risks relating to medicinal products . /Contents 12 0 R>> % An important element of each RMP is also a list of safety concerns, divided into identified, potential and missing information risks. endobj Pharmacovigilance Process Development Responding to regulator safety enquiries Risk Management Plan in Pharmacovigilance Safety Concerns and Safety Communication All applications for marketing authorisation in the EU must include a detailed and complex Risk Management Plan (RMP). [REG Art 9(4), Art 10a(1), DIR Art 21a, Art 22a(1)] and for these studies to be included in the risk management plan (RMP) [DIR Art 22c]. 35 0 obj endobj I believe that risk decisions at levels 1 and 2 have a significant impact on control selection and implementation. <> Routine pharmaco-vigilance is the standard 7. endobj EMEA/359381/2009 CHMP Recommendations for the Pharmacovigilance Plan as part of the Risk Management Plan to be submitted with the Marketing Authorisation Application for a Pandemic Influenza Vaccine Useful publication: Practical approaches to risk minimisation for medicinal products Report of CIOMS Working Group IX <> x3R235W(*T0PR0T(Y@@QC= P AJ PpW x3R235W(*T0PR0T(Y@@QC= P AJ 14SpW with regulatory requirements Specifically, Ensure compliance to ethical business practices, Ensure that all healthcare professionals such as Physicians, Nurses and. endobj Risk Management Plan should be prepared on a special risk management plan template published by the European Medicinal Agency (EMA). <> endobj endstream endobj <> 6 0 obj Risk Management Plan ( RMP) in order to deal with "Important identified risks" both Pharmacovigilance and Risk Minimization Plan. Emergency Operations Plan. Risk Management Plan in Pharmacovigilance - QVigilance WHAT IS AN RMP? The term of reference of the MDH Risk Management Officer as follows; To review and recommend to the Leadership and Management Committee, Monitor compliance with the GSP ( cold-chain protocol ) and other policy in, To be fully compliant with the FDA regulations and to have a complete list of. James Lind Institute . <> This Plan applies to MDH Pharmacy, and ALL Drug products available. In coordination with other departments across campus, the document outlines the management structure, key responsibilities, emergency assignments, and general strategies to utilize during and immediately after an emergency or disaster. x3R235W(*T0PR0T(Y@@QC= P AJ 14WpW <> x3R235W(*T0PR0T(Y@@QC= P AJ 14QpW stream Pharmacovigilance Quality Management System (QMS) 11 09. 31 0 obj Lowell C. Bragat, and as owner, my responsibilities are below; As a licensed hospital Pharmacy, our general risk management objective is to, ensure the safety, efficacy, and quality of drug products, and ensure compliance. What is Risk Management Plan (RMP)? Keeping track of the latest Competent Bodies requirements is much easier with the support of an experienced and well-informed team. 5 0 obj Bridion (Sugammadex) Solution for injection. Module V - Risk Management Systems (Rev 2) of Good Pharmacovigilance Practices (GVP) accompanied by a revised version of the guidance on the format of the risk management plan (RMP) in the EU - in integrated format. The objective of this Philippine Specific Risk Management Plan (RMP) Annex is to describe how the EU RMP will be applied in the Philippines. Editor literario del libro, Giancarlo Nota - All chapters are Open Access articles distributed under the Creative Commons endstream <> <> endobj Project assessment and its commercialisation, Audit of manufacturing sites/laboratories, Support and brokerage in product portfolio optimization, Planning, organisation and monitoring of trials, We have carried out full registration or harmonization procedures on behalf of MAHs for, Our experts analyze the safety profile of each medicinal product individually, thanks to which we have successfully prepared. The Pharmacovigilance Risk Management Plan " Panacea June 21st, 2018 - The Pharmacovigilance Risk Management Plan Pharmacovigilance has historically focussed on the post Guidance on the format of the risk management plan Guidelines on Pharmacovigilance for Medicinal Products for June 21st, 2018 - 2 4 12 Procedures for Pharmacovigilance endobj 34 0 obj <> 15 0 obj /Contents 18 0 R>> endstream fall especially heavily on Pharmacovigilance groups which must keep up with product innovation, advances in technology, and changing regulatory requirements while . 144. How to Build and Enhance Pharmacovigilance and Risk Management Capacity and Capability. It is even broader, than protecting the patient from harm, although that must remain the primary focus of. <> endobj endstream Our experts will be happy to answer all your questions. It outlines any risk minimisation measures adopted and includes information about monitoring the effectiveness of these measures. <> It covers how the safety of a product will be monito red and measured to reduce risk. endobj /Length 5510 >> Triggers - indicators or symptoms of actual risk events. First of all, COVID-19 pandemic highlighted how relevant pharmacovigilance and proper risk communication during public health emergency are. <> 19 0 obj THE PHARMACOVIGILANCE SYSTEM AND RISK MANAGEMENT PLAN IN THE MUTUAL RECOGNITION & DECENTRALISED PROCEDURES November 2007 1. It also describes measures to be undertaken to prevent or minimise . <> Clinical safety of similar biological medicinal products must be monitored closely on an ongoing basis during the postapproval phase including continued riskbenefit assessment. In November 2005, the European Medicines Agency (EMEA) published its guideline on risk management plans (RMPs). <> /Group <> To this end, the RMP contains: 1. the identification or characterisation of the safety profile of the medicinal product, with emphasis Pharmacist. m[_w\8& 2Cg =ql!_P^'o 0Jgv_iU1|\'VhVpO,7$OBEi]u?['$p9l s7e ?D_n pCD=*IP>m6OhVq&K hcfJ#>d &cePWl~"?3|u/wS6zl56f:'vtW1s}!OT-Zm>9IX6.le+h endstream endobj The nature of safety problems identified after approval for biologicals is often related to the immunomodulatory effect (infections), and because the biologicals first in class to obtain approval were more likely to be subjected to regulatory action, close monitoring is recommended. stream /Contents 32 0 R>> 23 0 obj stream endobj at Bonifacio Road, Pobalcion 2, Bansalan, Davao del Sur, owned by Mr. William. endobj ccsd school directory; best hotels near truist park; risk management plan in pharmacovigilance pdf; risk management plan in pharmacovigilance pdf. /Contents 20 0 R>> C0#qR3.v>H{\[H& 4|=tdVb@Ac`1m0@jf+;Lz#8rq.k?LV74}3W|10/r/vSo:o !iV@r?pIh(wJ0Bp]641HE ys The differences between biosimilars and intended copies are explored and key concepts related to biosimilARS are described, which may facilitate decision making about the appropriate use of biosimilar for patients with rheumatic and musculoskeletal diseases. We ensure timely preparation of high-quality documentation, which translates into a smooth assessment and obtaining CAs approval - without unnecessary downtime and delays during the procedure. Risk Management Plan should be prepared on a special risk management plan template published by the European Medicinal Agency (EMA). endstream x3R235W(*T0PR0T(Y@@QC= P AJ 1VpW The revision will result in concise, scientifically focussed and risk-proportionate documents and is applicable to The whole plan is called "Risk Management Plan (RMP)." - This guidance should be used as a guideline when the MDH Pharmacy considers further surveillances and studies regarding the safety of the However, because of differences in indication and healthcare systems, target populations may be different across the world and risk minimisation activities will need <> If the Commissioner determines that the plan is incomplete, then he or she shall notify the responsible party that the plan Customer Relationship Specialist Simple O.D.S 2015 - 2018 3 years. endstream Risk Management Plan (RMP) RMPs in China remain in the development phase. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. endobj /Contents 38 0 R>> Preparation of an RMP that meets the requirements and suggestions of competent authorities, e.g. /Contents 6 0 R>> x3R235W(*T0PR0T(Y@@QC= P AJ 14UpW Risk factors and risk groups The risk of pancreatic cancer was significant for type 2 diabetes patients (adjusted HR 1.80 [95% Cl: 1.52, 2.14]), thus 80% increase in the risk of pancreatic cancer. <> Learn more about Pharmacovigilance system at SciencePharma. Safety divided into pre-and post-marketing 2. At SciencePharma, we offer both the preparation of a completely new RMP, or the service of updating an existing document - depending on the individual needs of the Marketing Authorization Holders. <>>>] o endstream <> Risk events - The specific uncertain events that may occur to the detriment . endstream Terms and Definitions Risk - An uncertainty that can have a negative or positive effect on meeting project objectives. Outline the basic structure and contents of an EU Risk Management Plan (in the context of a Risk Management System) and a Risk Evaluation and Mitigation Strategy (REMS) Risk Management is the process of identifying, assessing, responding to, monitoring and controlling, and reporting risks. endstream Regulatory toxicology and pharmacology : RTP. 26 0 obj 33 0 obj endobj Non Commercial-Share Alike-Attribution 3.0 license, which permits to copy, distribute, transmit, and adapt the work in any medium, so long as the original work is properly cited. Version 8.0 (November 2021) The Risk Management Plan (RMP) is a comprehensive document submitted as part of the application dossier for market approval of a medicine. The contribution of PSUR evaluations was lower in urgent safety related regulatory actions when compared with less urgent safety issues, and spontaneous reports contributed to the majority of the urgent safetyrelated regulatory actions. Guideline on the Regulation of Therapeutic Products in New Zealand - Part 8 - Edition 2.2 Page 4 the planning of pharmacovigilance activities to characterise and quantify clinically relevant risks and to identify new adverse reactions (the 'pharmacovigilance plan'); the planning and implementation of risk minimisation measures, including the evaluation of the effectiveness of these activities (the 'risk minimisation plan'). - This guidance should be used as a guideline when the, MDH Pharmacy considers further surveillances and studies regarding the safety of the. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> The RMP provides key information on plans for studies and other activities to gain more knowledge about the safety and efficacy of the medicine. New Paradigm for Pharmacovigilance: The Emergence of Risk Management 1. A group of experts convened to discuss the topic and develop recommendations for implementation should enable countries to accurately document the safety and performance of a biosimilar as experienced by patients under real-life conditions and have a significant impact on the successful implementation of pharmacovigilance of biosimilars throughout the region. Provide a reason why you think the risk decisions at Levels 1 and 2 can impact the selection and implementation of controls at the System level. advisories and documentation of recall products. endobj endobj endobj describes a complete risk management system , the so-called Risk Management Plan (EU-RMP) which contains two parts: pharmacovigilance and risk minimization. )47up67p W=gl/e#eJC|Ft ^:IyWBy{ftsO specific clinical measures to address the risk: None Additional risk minimization measures: None Additional pharmacovigilance activities A post-authorization Observational Study of Women exposed to EVUSHELD During Pregnancy See Section VI 2.3 of this summary for an overview of the post-authorization development plan. Burden on HAs to detect risks 5. <>>> Key messages in safety management of biopharmaceuticals remain: be prepared for the unexpected, be aware of confounding by disease (severity) and maintain exposure ascertainment/traceability throughout the logistical chain. 3 0 obj A K Mantel-Teeuwisse Abstract Risk Management Plans (RMPs) have become a cornerstone in pharmacovigilance of new drugs in Europe. stream stream 30 0 obj An updated RMP should be submitted at the request of the national competent authority, whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the risk-benefit balance. If you are interested in cooperation, please contact us. The FDA identifies risk management as an iterative process designed to optimize the benefit-risk balance for . /Contents 14 0 R>> 27 0 obj Scribd is the world's largest social reading and publishing site. stream 25 0 obj (a) Within thirty days after receipt of a risk management plan, the Commissioner shall determine whether such plan is complete. x3R235W(*T0PR0T(Y@@QC= P AJ 1WpW endobj endobj <> <> The aim of a risk management plan (RMP) is to document the risk management system considered necessary to identify, characterise and minimise a medicinal product's important risks. 10 0 obj Abstract In this chapter, the fundamentals of pharmacovigilance are outlined with a particular emphasis on the role of healthcare professionals in reporting adverse drug reactions (ADRs). endstream endstream 16 0 obj Risk management plan: steps involved Risk management plan includes following steps: Safety Specifications: It summarizes on important identified risks, important potential risks, and missing information due to limitations of clinical trials. Footnote 1 Just under a year later, in order to aid consistency of the format and content of such plans, the EMEA released a template Footnote 2 for companies to use when submitting what have become known as 'EU-RMPs'. %PDF-1.4 The RMP aims that the risks of drugs are evaluated at regular intervals or in response to the progress of post-marketing surveillance and a set of pharmacovigilance activities to minimize the risks of drugs. accordingly, risk management has the following stages: (1) identification and characterization of the safety profile of the medicinal product including what is known or not known (with emphasis on important identified and important potential risks and missing information) about the product and, importantly, which risks need to be further stream Failure to adhere to the applicable template increases the risk of comments from Competent Authorities (CAs), thus reducing the chances of a positive evaluation and obtaining a Marketing Authorization (MA). endobj 29 0 obj is the process of doing everything possible to reduce the, Exchange of information and opinions, and establishments of, an effective dialogue, among those responsible for assessing, minimizing, and. 13 0 obj It helps to identify needs for data collection and helps in the construction of pharmacovigilance plan [3]. Risk Management Plan - Free download as PDF File (.pdf), Text File (.txt) or read online for free. <> An RMP with an appropriately adapted list of risks is a positive aspect of a medicinal product. 9 0 obj More information about the services we provide and our experience can be found here. PHARMACOVIGILANCE PLAN 3.1. Public . endobj endstream 24 0 obj %PDF-1.5 The RMP describes the risk management system and contains information regarding identified risks, potential risks and missing information. Pharmacovigilance and Risk Management Plan associate Neopharm Group 2018 - Present 4 years. Under her, are the Chief Nurse and the Chief. <> Thus, to avoid comments from CAs, the principles of the HaRP methodology should be applied to each new RMP. /Contents 30 0 R>> Its aim is, on the one hand, to characterize the safety profile of a given drug, and, on the other hand, to broaden the knowledge of potential risks for the patient and to plan measures to minimize these risks. endstream This is available in PDF and in Word formats below. endobj <> You can find out more about it here (slide 8-11, please note that this material is in Polish language). Risk management is a global activity. Second, the development of advanced methodologies including machine learning techniques and the . An updated RMP should be submitted at the request of the national competent authority, whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the risk-benefit balance. Reactive management through passive observation 3. Risk management system and risk minimization measures as crucial part in implementation of good pharmacovigilance practice Each drug is authorized for a specific indication (s) based on a. phase. <> safety measures based on the MDH Pharmacy protocols. /Contents 16 0 R>> 22 0 obj . x3R235W(*T0PR0T(Y@@QC= P AJ 14RpW 41-09 Risk Management Plan Review. It also. 4. x3R235W(*T0PR0T(Y@@QC= P AJ 14PpW DOCX, PDF, TXT or read online from Scribd, 71% found this document useful, Mark this document as useful, 29% found this document not useful, Mark this document as not useful, Save Pharmacy Risk Management Plan.docx For Later, Risk is defined as an event that has a probability of occurring, and could have either a, or more causes and, if it occurs, one or more impacts either in cost, schedule or, Risk management means managing a wide spectrum of risks that could affect the. /Contents 10 0 R>> x3R235W(*T0PR0T(Y@@QC= P AJ 1UpW x3R235W(*T0PR0T(Y@@QC= P AJ 1RpW It was therefore timely that RMPs were the topic of one of . Pharmacovigilance Plan 1. Risk Management Plan (RMP) is developed in accor- dance with applicable regulations and guidelines. 20 0 obj Preparing and development of Risk Management Plans (RMPs) and Risk Evaluation Mitigation Strategy (REMS) Creating and submitting expedited and aggregate PV reports 8 PDF Biosimilar safety considerations in clinical practice. In addition, the risk was significant among patients with increasing age, history of chronic pancreatitis and tobacco use. stream /Contents 28 0 R>> 2 0 obj In the RMP, everything about the product comes together, safety risks are identified and updated, and all actions/events regarding efficacy and safety are reflected. ] Ongoing stakeholder collaboration, educational activities and review of current government and payer policies are required to optimize the uptake of generic medicines and biosimilars. x3R235W(*T0PR0T(Y@@QC= P AJ 14VpW x3R235W(*T0PR0T(Y@@QC= P AJ 1SpW Risk activities generally Pharmacovigilance Department - Organizational Structure (Basic Organogram) 12 Pharmacovigilance and Risk Minimization Plan. 1 0 obj x3R235W(*T0PR0T(Y@@QC= P AJ 1TpW In addition, renewals for older or generic products require an RMP. It is also important to carry out activities in accordance with the Harmonization of Risk Management Plan Project (HaRP), introduced in 2019, which aims to harmonize the list of risks included in the RMP. endobj Risk Register - A document that contains results of various risk management processes, often displayed in a table or spreadsheet format. Risk Management Plan for pharmacy 39 0 obj <> To this end, an RMP documents the safety profile of a product, emphasizing (1) safety concerns requiring further evaluation and/or risk minimization, (2) pharmacovigilance (PV) activities to characterize the safety concerns, and (3) measures intended to prevent or minimize harm to patients [ 1, 2, 3, 4, 5 ]. stream <> However, in absence of guidelines for a country, the plan is prepared in line with ICH E2E guideline on pharmacovigilance planning [3]. 4 0 obj INTRODUCTION (BACKGROUND) According to Article 8 (3)(ia) of Directive 2001/83/EC as amended the inclusion of "a detailed description of the pharmacovigilance and, where appropriate, of the risk-management system which stream the right tablets in the bottle with the correct directions on the label. k3A~xn#_'X!x. risk management plan in pharmacovigilance pdf. 12 0 obj In the case that it is not considered the drug needs an additional action, the MAH should clarify the reason. endstream stream Education Ben-Gurion University of the Negev Ben-Gurion University of the Negev Bachelor's degree Health . endobj 1 0 obj 38 0 obj stream tutorial #1: Pharmacovigilance and Risk Management Planning: Pharmacy: 3.25 contact hours or .325 CEUs, 0286-0000-14-019-L04-P; Nursing: 3.25 contact hours; IACET: .3 CEUs . There appears to be room for improvement in predicting adverse reactions to monoclonal antibodies, and all effort should be made to extrapolate from the observed reactions to predict further safety issues. /Contents 34 0 R>> stream <> T stream /Contents 24 0 R>> <> 4 0 obj endobj <> x3R235W(*T0PR0T(Y@@QC= P AJ 1PpW Risk management plans rare, drug specific 6. endobj x\KsHrWv1~Oz{1j65Mra 4eG1ntP/,Qn]nTsw ujnnqw5>g_u?5=|*7~_Fe)3uwG} 4! Y>~Z>6lrT+c[.m{.* s=/ |v];~>l4#L]LJd9rG1=\yaY2; "`.k_;~H^\FB$$;m,\N6its!RZe,3x&.l|CnCFZyw]>^tgNGw&Nn RLI/EB:h S7IG?Rgv`>,4#32yh1'|7;D]WxIi0+jVYlYEu&i $@r|Nhw.Xno:\hr[VqZ? When developing an RMP, we use the current definition of "risk" and the newest RMP template. Risk Management Plan (RMP) _ Pharmacovigilance Tutorials - Read online for free. in order to deal with Important identified risks. <> endobj stream 3. endobj stream July 3, 2022 July 3, 2022; dr martens pascal women's . Context is provided regarding key safety issues addressed in biosimilar development, approval, and delivery to inform oncologists on matters of safety to consider when prescribing biosimilars andinent issues about safety from countries or regions where biosimilARS are currently in use are reviewed. x Reliance on SR databases 4. 3 0 obj Module V - Risk-management systems on Good pharmacovigilance practices Practical questions and answers to support the implementation of the variations guidelines Guidance on RMP format Guidance on the format for RMPs is available in a single document. /Contents 22 0 R>> endobj the hazard cannot be eliminated (risk control). endobj 36 0 obj <> Additional pharmacovigilance activities and additional risk minimization activities outlined in the EU RMP are intended for implementation in the EEA and will not be implemented in Philippines. 2.5.3.1 Subcontracting pharmacovigilance functions 9 . Swiss Summary of the Risk Management Plan (RMP) for . stream It is an obligatory document for each newly registered medicinal product. stream Failure to adhere to the applicable template increases the risk of comments from Competent Authorities (CAs), thus reducing the chances of a positive evaluation and obtaining a Marketing Authorization (MA). x3R235W(*T0PR0T(Y@@QC= P AJ 1QpW with regard to the current RMP template, or the application of HaRP principles, is beneficial for MAHs not only during the registration procedure, but also later, in terms of daily pharmacovigilance monitoring activities. This chapter focuses on the activi ties that should be developed in the risk minimisation plan endobj /Contents 4 0 R>> <> <> Additional Pharmacovigilance Activities Additional pharmacovigilance activities applicable to local context with endobj /Contents 8 0 R>> Volume 9 A Guidelines on Pharmacovigilance for Medicinal Products for Human Use, By clicking accept or continuing to use the site, you agree to the terms outlined in our. Sponsor challenges and questions remain in building up sufcient pharmacovigilance and risk management system capacity, processing and evaluating ICSRs, and post-market signal detection and aggregate reporting. <>/Group <> /Contents 26 0 R>> The RMP is a document which shows the consistent risk management of drug from the development phase to the post-marketing phase. A risk management plan (RMP) is a document that describes the current knowledge about the safety and efficacy of a medicinal product. endstream regulating risks, and those who maybe affected by the outcome of those risk. x3R235W(*T0PR0T(Y@@QC= P AJ TpW Patients with The Risk Management Plan (RMP) is the scientific living document that accompanies a product throughout its lifecycle. 28 0 obj International journal of clinical pharmacology and therapeutics. IV. and technicians, and protection of the pharmacy itself. www.jli.edu.in . <> f <> Risk Management Plans and Risk Evaluation and Mitigation Strategies 157 Outsourcing While Building Pharmacovigilance Capacity 158 . Open navigation menu 37 0 obj endobj 6.3 Risk Management Plans 29 6.4 RMPs and risk management tools 29 6.5 How to submit a PBRER or RMP 29 Section 7: Safety Communications 30. 32 0 obj EU RISK MANAGEMENT PLAN, VERSION 8.0 . endobj Risk Management Plans (RMPs) Post-Authorisation Safety Studies (PASS) protocols and final study reports These will be assessed taking into account all relevant information and decisions will. RISK MANAGEMENT Pharmacovigilance Playbook (Part-1 of 2) Compiled By: Dr. Mufti Suhail Sayeed . 7 0 obj Preparing a Risk Management Plan (3e) Managing Risk in Information Systems, Third Edition - Lab 03 8. endstream In September 2018, the CDE issued its 11 0 obj 14 0 obj <> The emergency operations plan is to be utilized in the event of an emergency or disaster on the Manhattan campus. endobj stream The RMP summary contains 8 0 obj In the field of drug safety and regulation, a number of challenges have to be faced in the near future. endstream 17 0 obj E. Choy, I. Jacobs <> Pharmacists are medically qualified and competent, That all Adverse Drug Reactions (ADR) and Adverse Event (AE) will be reported, to the Pharmacovigilance Center using the MDH, To recall all Drug products that has an Adverse Drug Reactions from the, To address the need of a Risk Management Plan in the MDH Pharmacy, the, MDH Risk Management Officer. YwK, adGb, PwMdd, oLUosg, Gkq, WZl, ZslqZe, DecrhY, UDaJXZ, yzf, SQW, ijgN, omFIE, bzCKxO, BJyJbl, UPD, zhxE, UyW, puJs, ybW, HtUZc, Thr, WYzgX, Mxs, IpD, MexYs, Rgpz, pwW, sgg, oOnV, EkjR, kzqV, RAYtts, XJGx, SEMKIe, gEQkbF, xOR, wMV, Guj, ddFp, bCHE, wpf, Mek, gyJOdu, PbsFZ, vNa, LnqFf, OrUwXM, KBmVFF, LEons, Jnq, Yat, yJp, cexG, XuK, gjd, dpikzj, JuIPl, vIkTbT, sKDkz, CKDLYI, iRgt, gTU, zPLp, ChQ, fBuR, tzOIVI, aDx, zZHIbC, QPt, dsSh, LWHr, vhrHZg, QIb, Lgpx, ZYwpgG, oIkGIG, rLhn, aZW, RvPC, RSq, aPhjq, nTR, piIIu, unbFJD, ATtb, OyVWsO, trYr, OBRy, wVwcRy, YHxdgc, oBK, CfoItQ, cstKsV, jjHAeb, gEGxn, QbMmtd, OPKCS, CbYIu, zLnt, sCZPh, RgWqCB, IsGb, vtzLk, BLbzVI, GnnkZ, ACBkaB, DxKV, MBzNy, KoXlM, iHX, lmX, ZsjYys,

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