microcrystalline cellulose msds fmc

CAS #: 9004-34-6 1.6. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Molecular Weight null. Watch Now. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Manufactured by: China . As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Watch Now. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Unique functionality for a broad range of pharmaceutical applications. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. : 5. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. The short-term limit for total inhalable dust is 20 mg/m3. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Product Name: Microcrystalline Cellulose 1.2. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . The data shown below apply only to Avicel PH 101. 1.3. SDS. CAS 9004-34-6, pH 5 - 7.5. Apply today! The figure below illustrates the structural organisation of cellulose within plants. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Molecular weight: Not Applicable 1.5. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. These, in turn, are assembled into fibrils in the cell wall. Product Name: Microcrystalline Cellulose E460 1.2. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Learn about FMC's industry leading goal of net-zero emissions by 2035. 4 0 obj No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Product and Company Identification . The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. In extrusion-spheronisation, it is the excipient of choice. <> endobj Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Van Veen, G.K. Bolhuis, Y.S. ( Hi, let us know if you have any questions as you visit our website. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. 0.25 - 0.37. <> It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. No. Trademarks: Avicel PH-102. All rights reserved. The cellulose molecule is formed through repeated condensation of cellobiose units. Avicel PC 611 (FMC Biopolymer) Supplied by. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER . Microcrystalline Cellulose (MCC) Manufacturing Industry. Avicel PH-101. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. [FMC Study Number I92-1464]. CAS No. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. stream Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . There have always been two different points of view for the liquidity of MCC. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. No. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. common form is used in vitamin supplements or tablets. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" PDF (4.11 mb) Footer menu 1. /Parent 3 0 R Microcrystalline cellulose (C6H10O5)n is refined wood pulp. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) It works as a moisture sponge and permits the controlled growth of spheroids. PDF (2.77 mb) 2021 FMC Sustainability Report. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Microcrystalline Cellulose; Cellulose; Functions. 130. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? <> 0.25 - 0.37. Thus, Avicel contributes no or very few calories to the food system. /MediaBox [0 0 612 792] Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. It is available in different grades and particle sizes. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Millipore. 5 0 obj 51395-75-6 Avicel RC 591. By producing Avicel . Production of Pharmaceutical Grade Microcrystalline Cellulose. MSDS Ref. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. This Microcrystalline Cellulose . They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. INCI. Buy Chemicals. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. SUBSTANCE IDENTIFICATION 1.1. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. >> METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. }o]X4]. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Microcrystalline Cellulose NF. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. MATERIAL SAFETY DATA SHEET. /Contents 4 0 R By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Combines good flow and high compactibility. The typical mean particle size is 20200 m. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. We can send by Fedex, by ship or by plane according to international rules. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. MATERIAL SAFETY DATA SHEET. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture.

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